HIV-infected H9 T cell

Future Topic: Immunology & Inflammation

The Initiative and Networking Fund of the Helmholtz Association

The Initiative

Five Helmholtz Centers are joining forces in a new initiative that aims to advance immunology research and the development of new therapies. The MDC is coordinating the long-term project, which was launched in November 2017 with a three-year program.

There is a mood of optimism among the immunology community, because the past few years have seen great strides made in immune system research. The first immunology therapies have been approved, while others are being tested in clinical trials. Researchers are uncovering ever more details about the complex system of organs, tissues, and different cell types that make up the human immune system.

The initiative entitled “Immunology & Inflammation” brings together immunology research – which is spread out over various Helmholtz Centers – in a common structure. Of twenty projects, six are organized as “tandem” projects in which laboratories of different Centers work closely together.

MDC researchers Michela Di Virgilio and Klaus Rajewsky are leading and coordinating the initiative. It is the nucleus for an undertaking that intends to position the Helmholtz Association as a main player in application-oriented immunology research internationally.

 

Key scientific questions addressed by the initiative

  • How is the tissue specificity of immune cells generated and how is it affected by environmental influences, plasticity and the tissue microenvironment? 

  • What is the mechanistic link between infections, immune reactions and their microenvironment, inflammatory responses and central nervous system disorders, including neurodegenerative disease, and how can we use this information to better understand and treat these disorders? 

  • How can our knowledge of the immune system be applied to develop innovative therapies, including the identification of novel antigens for immune therapies and gene repair strategies in monogenic immune diseases?

The Helmholtz Centres have a broad repertoire of state-of-the-art technologies and expertise to work on these topics. Examples are CRISPR/Cas9-mediated mutagenesis, genetic mouse models, cell-fate-mapping, organoids and tumor explants, as well as GMP production of pharmaceuticals and many years of experience in conducting clinical studies.

Aside from new and joint research projects, the training of the next generation of basic and clinical researchers in immunology, as well as scientific exchange, is also in the focus of the future topic.

Featured picture: Scanning electromicrograph of an HIV-infected H9 T cell. Credit: NIAID, cc-by-2.0

Team

These 23 research teams are taking part in the initiative:

Max Delbrück Center for Molecular Medicine (MDC)

The MDC is devoted to understanding the molecular basis of health and disease, with a focus on disease mechanisms at a system-wide level and the translation of findings into clinical applications.

It cooperates closely with Charité, a large university hospital in Berlin. Joint institutions include the Experimental and Clinical Research Center (ECRC ) und the Berlin Institute of Health (BIH).

One of the research areas at the MDC is immunology and inflammation, which covers tumor immunology, DNA repair in B lymphocytes, the role of tumor stroma-immune cell interaction in cancers, the role of innate immune cells in gliomas and neurodegenerative diseases, and the development of immunotherapy strategies.

The MDC’s participating research groups bring a broad range of technological expertise to the initiative – ranging from biochemical assays, structure and function analysis, and gene editing to the development of preclinical mouse models, GMP production, and even clinical trials.

German Cancer Research Center (DKFZ)

The DKFZ is a multidisciplinary center covering cancer biology from basic molecular and cell biology to clinical research and care.

Through the National Center for Tumor Diseases, a joint venture between the DKFZ, Heidelberg University Hospital, and German Cancer Fund, the DKFZ has access to patients for research from bench to bedside and back. The participating groups of the DKFZ bring in broad expertise in fundamental and clinical tumor immunology, the link between cancer, chronic inflammation and viral infection, neuroimmunology, and immune surveillance of tumors.

The center will contribute technological expertise crucial to the success of the proposal, such as the generation and characterization of pre-clinical mouse models, in vivo fate mapping, GMP production, and innovative clinical trials.

German Center for Neurodegenerative Diseases (DZNE)

The DZNE focuses on neurodegenerative disease, covering both research on the fundamental molecular and cellular basis of neurodegenerative disease as well as clinical and population research.

The participating groups cover an especially exciting area of research, namely the link between innate immune and inflammatory mechanisms to neurodegenerative disease. The center will provide expertise on profiling neurodegeneration, neuroinflammation and neuronal function including in vivo imaging, CNS histology, generation of human-derived cellular models, and their functional assessment under physiological and pathological circumstances.

Helmholtz Zentrum München (HMGU)

The HMGU aims to contribute significantly to a better understanding of major non-communicable common diseases which develop from lifestyle, environmental factors and personal genetic background, most notably diabetes and allergy.

The overall goal of HMGU’s research is to elucidate the complex disease causes and to develop innovative approaches for their precise diagnosis, prevention and therapy. The participating groups bring in their expertise in the basic molecular mechanisms of T cell signaling, activation, and tolerance, as well as T cell immunity and immunotherapy in diabetes, allergy and lung diseases.

The center will contribute important technological expertise in the generation and provision of novel pre-clinical mouse models, tools to fate map tumor cells and immune cells, and a translational approach for CRISPR/Cas9-based gene therapy of monogenic diseases.

Helmholtz Centre for Infection Research (HZI)

The HZI has expertise in the area of infectious diseases, investigating the fundamental principles underlying infection processes to develop innovative approaches to prevent, diagnose and treat infectious diseases.

In this context, the host’s innate and adaptive immune responses to infection, evasion mechanisms that allow pathogens to circumvent the host defenses, and underlying mechanisms of pathogen clearance are dissected.

Within this proposal, the HZI will contribute expertise in epigenetic imprinting for the identification of immune cell subsets, epigenome-editing of T cells using CRISPR/Cas9, predictive mathematical models, mouse behavioral analysis, as well as expertise in clinical trials and GMP production of antibodies and immune cells.

Research

Inflammation processes and interactions between the adaptive and innate immune systems play a major role in both infections and cancers – as well as in nearly every widespread human disease.

Since a comprehensive approach to the immune system would be as complex as the system itself, we concentrate on three interconnected central and timely topics in immunology, which are addressed in three scientific work packages (WP).

WP 1. Tissue-Specific Immune Cells

WP1 concerns the factors that determine the tissue- and organ-specificity of immune cells, a topic that is gaining rapidly increasing attention and may become ever more central in understanding as well as treating immune-related diseases. Decisive factors will be tackled in the following aims:

  1. the genetically determined developmental programs that lead to immune cell specificity and function,
  2. the influence of external (environmental) factors on innate and adaptive immunity and its plasticity,
  3. the effects and mediators of the tissue microenvironment in shaping immune cell functions, and
  4. as a specific example the interplay of tumor microenvironment and cancer cells, which allows the latter to escape immune surveillance.

WP 2. Immunity, Infection and Inflammation in the CNS

WP2 explores a second major example of the impact of a specific environment on the immune system by addressing the characteristics of immunity, infection and inflammation in the central nervous system (CNS), processes that have recently been demonstrated to play major roles in many CNS disorders, notably neurodegeneration, but also neuropsychiatric diseases. Its specific aims concern

  1. functional and regional diversity of microglia, the innate immune cells of the CNS,
  2. microglia-mediated inflammation as a major causative mechanism in neurodegenerative disorders, and
  3. the interplay between infection and neurodegeneration, an interplay that occurs both in CNS-based and peripheral infection.

WP 3. Innovative Therapies

WP3 addresses innovative therapies that result from research of WP1 and WP2 and enables the translation of these findings into the clinic. Based on the first, currently ongoing clinical trials of such innovative therapeutic strategies, notably in cancer, the specific aims of WP3 will cover

  1. harnessing the adaptive and innate immune response against tumors,
  2. the search for and characterization of novel antigens for targeted T cell therapy, the bottleneck in cellular therapies, and
  3. CRISPR-Cas9 mediated gene therapy of monogenic immunodeficiencies as pioneer projects.

Synergies

A key aim of the initiative is to bring together a community of excellent researchers from all centers in the Helmholtz Research Field Health.

Several collaborative efforts within the consortium already exist and have yielded results which could not have been achieved by single research groups. Examples include common studies investigating connections between infections (HZI) and neurodegeneration (DZNE), or studies on the role of inflammation in metastasis and dissemination of tumor cells (DKFZ) and (MDC), as well as the role of chronic inflammation (DKFZ) and programed cell death in controlling DNA damage (MDC).

To enable and foster projects that cannot be done at a single Helmholtz Center, we have enhanced interactions by funding six collaborative projects, i.e. projects implemented by pre- and/or post-doctoral researchers who are supervised by two PIs from different centers:

  • TCR gene therapy of pancreatic cancer through coordinated attack by mutanome-specific CD8+ and p53-specific CD4+ T-cell. Supervisors: Rienk Offringa (DKFZ) and Thomas Blankenstein (MDC)

  • A combined in vitro and in silico analysis of microglia activation to assess the potential of the voltage-gated proton channel HVCN1 as a therapeutic target in Alzheimer’s disease. Supervisors: Melania Capasso (DZNE) and Michael Meyer-Hermann (HZI)

  • Impact of AHR signalling on immunity. From structure to function. Supervisors: Michael Platten (DKFZ) and Oliver Daumke (MDC)

  • Mechanistic analysis of lymphoma-triggered dissemination to brain, liver and lymphoid tissue through crosstalk to stromal cells. Supervisors: Mathias Heikenwälder (DKFZ) and Uta Höpken (MDC)

  • Impact of nasal pollen exposure on the inflammatory milieu within the brain and the control of neurotropic virus infections (NaPo-BRAIN). Supervisors: Claudia Traidl-Hoffmann (HMGU) and Ulrich Kalinke(HZI)

  • Towards therapeutic gene editing in monogenic primary immunodeficiencies. Supervisors: Klaus Rajewsky (MDC) and Ellen Renner (HMGU)

Activities

I & I Symposium on Covid-19

March 3, 2021, virtual

I & I  3rd Retreat

September 30 - 1. October 2020

The 2020 I&I retreat will be held online. Please, follow the link below to register yourself.

I & I Talks and Lab Visits

 

PhD students and postdocs from the participating labs are invited to go to a partner lab to give a talk and visit the lab.

 

Training Schools

 

PhD students and early-stage postdocs from the participating labs are invited to attend a training school. The project will also cover the attendance to Conferences and Workshops as long as the participant presents a poster or gives a talk. 

Recommended schools:

  • FEBS Immunology Summer School Link 
  • Schools organized by the DGfI Link 
  • Schools organized by the European Network of Immunology Institutes Link 

I & I 2nd Retreat

October 2019, Heidelberg

The info will be available soon.

Satellite Symposium - DGfI Meeting

September 10, 2019, Munich

All I & I researchers are welcome to join the Immunology & Inflammation Satellite Symposium that takes place in Munich on September 10, 2019. The Symposium is organized by Prof. Ellen Renner and Prof. Klaus Rajewsky. 

See the Program here. 

You can access the conference website here. 

1st I & I Conference

February 24-26, 2019, Berlin

Our 1st edition holds an exciting program that comprises four sessions covering the key new developments, their impact on life science, and implications for modern medicine. We have invited scientists among the top world-renowned experts for their standing in the field and contribution to the breakthroughs that fuelled these new areas of investigation. Young scientists will also be given the opportunity to present data through posters and short presentations. 

You can access the conference website here.

I & I 1st Retreat

November 26-27, 2017, Berlin

The I&I kick-off meeting and 1st retreat took place on 26-27 November 2017 at the Conference Venue of the Max Planck Society, Berlin. The consortium principal investigators were invited to shortly share their research work.

The agenda is available here.

Publications

January 2021, Journal of Clinical Investigation
mTOR-dependent translation amplifies microglia priming in aging mice
L. Keane, I. Antignano, S.-P. Riechers, [...] M. T. Heneka, M. Capasso

 

December 2020, Clinical Immunology
Class switch recombination defects: impact on b cell maturation and antibody responses
E. D. Renner, C. E. Krätz, J. S. Orange, Jordan, [...] T. R. Torgerson, H. D. Ochs

 

October 2020, iScience
An Adaptive Control Scheme for Interleukin-2 Therapy
S. Khailaie, G. Montaseri, M. Meyer-Hermann

 

October 2020, Neuron
Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer’s Disease
J. W. Lewcock, K. Schlepckow, G. Di Paolo, S. Tahirovic, K. M. Monroe, C. Haass

 

September 2020, Acta Neuropathologica Communications
Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury
M. Ifuku, L. Hinkelmann, L. D. Kuhrt, [...] H. Kettenmann, L. S. Helmut

 

September 2020, Brain Behavior and Immunity
Deletion of muscarinic acetylcholine receptor 3 in microglia impacts brain ischemic injury
A. Costa, V. Haage, S. Yang, [...] S. A. Wolf, H. Kettenmann

 

September 2020, EMBO Reports
Loss of TMEM106B potentiates lysosomal and FTLD‐like pathology in progranulin‐deficient mice
G. Werner, M. Damme, M. Schludi, [...] C. Haass, A. Capell

 

September 2020, J Allergy Clin Immunol
Defining biomarkers to predict symptoms in subjects with and without allergy under natural pollen exposure
M. Gökkaya, A. Damialis, T. Nussbaumer, [...] A. U. Neumann, C. Traidl-Hoffmann, S. Gilles

 

August 2020, Molecular Therapy
CRISPR-Cas9-Mediated ELANE Mutation Correction in Hematopoietic Stem and Progenitor Cells to Treat Severe Congenital Neutropenia
N. T. Tran, R. Graf, A. Wulf-Goldenberg, [...] K. Rajewsky, V. T. Chu

 

July 2020, Journal of Experimental Medicine
PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification
V. Delgado-Benito, M. Berruezo-Llacuna, R. Altwasser, [...] A. Akalin, M. Di Virgilio

 

July 2020, Current Allergy and Asthma Reports
Antigen 5 Allergens of Hymenoptera Venoms and Their Role in Diagnosis and Therapy of Venom Allergy
S. Blank, M. L. Bazon, J. Grosch, C. B. Schmidt-Weber, M. R. Brochetto-Braga, M. B. Bilò, T. Jakob

 

June 2020, PNAS
Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis
T. Sommermann, T. Yasuda, J. Ronen, T. Wirtz, [...] A. Akalin, K. Rajewsky

 

June 2020, STAR Protocols
Protocol for Efficient CRISPR/Cas9/AAV-Mediated Homologous Recombination in Mouse Hematopoietic Stem and Progenitor Cells
N. T. Tran, J. Trombke, K. Rajewsky, V. T. Chu

 

May 2020, Toxins
Shedding Light on the Venom Proteomes of the Allergy-Relevant Hymenoptera Polistes dominula (European Paper Wasp) and Vespula spp. (Yellow Jacket)
J. Grosch, C. Hilger, M. B. Bilò, [...] C. B. Schmidt-Weber, S. Blank

 

May 2020, The Journal of Pathology
Deficiency in IκBα in the intestinal epithelium leads to spontaneous inflammation and mediates apoptosis in the gut
N. Mikuda, R. Schmidt‐Ullrich, [...] J. Wolf, U. E. Höpken, C. Scheidereit, A. A. Kühl, M. Kolesnichenko

 

May 2020, Cell Reports
Type I Interferon Receptor Signaling in Astrocytes Regulates Hippocampal Synaptic Plasticity and Cognitive Function of the Healthy CNS
S. Hosseini, K. Michaelsen-Preusse, [...] U. Kalinke, M. Korte

 

May 2020, Cell Reports
hGBP1 Coordinates Chlamydia Restriction and Inflammasome Activation through Sequential GTP Hydrolysis
A. Xavier, M.A. Al-Zeer, T.F. Meyer, O. Daumke

 

April 2020, Scientific Reports
Vitamin C supports conversion of human γδ T cells into FOXP3-expressing regulatory cells by epigenetic regulation
L. Kouakanou, C. Peters, [...] Jochen Huehn, D. Kabelitz

 

March 2020, World Allergy Organization Journal
Physical and immunological barrier of human primary nasal epithelial cells from non-allergic and allergic donors
C. Bergougnan, D. C. Dittlein, [...] C. Traidl-Hoffmanna, S. Gilles

 

February 2020, PLoS Pathogens
Selective reconstitution of IFNγ gene function in Ncr1+ NK cells is sufficient to control systemic vaccinia virus infection
K. Borst, S. Flindt, P. Blank, [...] U. Kalinke

 

February 2020, Allergy
Nasal-specific IgE correlates to serum-specific IgE: First steps toward nasal molecular allergy diagnostic
M. Gökkaya, V. Schwierzeck , K. Thölken, [...] C. Traidl‐Hoffmann, S. Gilles

 

February 2020, Immunity
Human Mast Cell Proteome Reveals Unique Lineage, Putative Functions, and Structural Basis for Cell Ablation
T. Plum, X. Wang, M. Rettel, J. Krijgsveld, T. B. Feyerabend, H.-R. Rodewald

 

February 2020, Nature Communications
Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas
K. Aslan, V. Turco, […] M. Platten

 

January 2020, Frontiers in Immunology
Precision Medicine in Hymenoptera Venom Allergy: Diagnostics, Biomarkers, and Therapy of Different Endotypes and Phenotypes
S. Blank, J. Grosch, M. Ollert, M. B. Bilò

 

January 2020, eLife
Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models
L. S. Monasor, S. A. Müller, […] C. Haass, S. F. Lichtenthaler, S. Tahirovic

 

January 2020, Journal of Experimental Medicine
Pdap1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification
V. Delgado-Benito, M. Berruezo-Llacuna, R. Altwasser , […] A. Akalin, M. Di Virgilio

 

January 2020, bioRxiv
Sequential MAVS- and MyD88/TRIF-signaling triggers anti-viral responses of tick-borne encephalitis virus-infected murine astrocytes
L. Ghita, V. Breitkopf, F. Mulenge, […] I. Steffen, U. Kalinke

 

January 2020, bioRxiv
Brain geometry matters in Alzheimer’s disease progression: a simulation study
M. Hoore, J. Kelling, M. Sayadmanesh, […] Michael Meyer-Hermann

 

January 2020, bioRxiv
Murine Staphylococcus aureus chronic infection is cured by theory-driven therapy
L. A. Papaxenopoulou, G. Zhao, S. Khailaie, […] M. Meyer-Hermann

 

November 2019, The Neuroscientist
Amyloid, APP, and Electrical Activity of the Brain
D. Hefter, S. Ludewig, A. Draguhn, M. Korte
doi:10.1177/1073858419882619

 

November 2019, Neuron
Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology
D. H. Gutmann, H. Kettenmann

 

October 2019, Trends in Neurosciences
Cien Años de Microglía: Milestones in a Century of Microglial Research
A. Sierra, R. C. Paolicelli, H. Kettenmann

 

October 2019, Nature Communications
Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology
J. Sonner, M. Keil, M. Falk-Paulsen, N. Mishra, […] M. Platten

 

October 2019, Cell Reports
Injection of Antibodies against Immunodominant Epitopes Tunes Germinal Centers to Generate Broadly Neutralizing Antibodies
M. Meyer-Hermann

 

October 2019, Brain Behavior and Immunity
Tenascin C regulates multiple microglial functions involving TLR4 signaling and HDAC1
V. Haage, N. Elmadany , L. Roll, A. Faissner, D. H. Gutmann, M. Semtner, H. Kettenmann

 

September 2019, Cell Reports
Efficient CRISPR/Cas9-Mediated Gene Knockin in Mouse Hematopoietic Stem and Progenitor Cells
N. T. Tran, T. Sommermann, R. Graf, […] K. Rajewsky, V. T. Chu
MDC

 

September 2019, Cancer Cell
Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention
T. O'Connor, […] U. E. Höpken, P. A. Knolle, L. von Baumgarten, U. Keller, M. Heikenwalder

 

August 2019, Allergy
Impaired memory B‐cell development and antibody maturation with a skewing toward IgE in patients with STAT3 hyper‐IgE syndrome
W. Veen, C. E. Krätz, C. I. McKenzie, […] E. D. Renner

 

June 2019, Nature Communications
STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus
P.-K. Tegtmeyer, J. Spanier, […] U. Kalinke

 

January 2019, Biophysical Journal
Mathematical model shows how sleep may affect amyloid β fibrillization
M. Hoore, S. Khailaie G. Montaseri, T. Mitra, M. Meyer-Hermann

 

August 2019, Cell Rep.
53BP1 supports Immunoglobulin Class Switch Recombination independently of its DNA Double-Strand D. Sundaravinayagam et al. 

 

April 2019, J. Neurosci. Res.
Microglial phagocytosis in ageing and Alzheimer´s disease
E. Gabande Rodriguez, L. Keane, M. Capasso

 

April 2019, Nat. Med.
Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer
M. Malehmir, D. Pfister, [...] A. Weber, M. Heikenwalder

 

March 2019, Front Immunol.
Discrepancies in the tumor microenvironment of spontaneous and orthotopic murine models of pancreatic cancer uncover a new immunostimulatory phenotype for B cells
S. Spear, J. B. Candido, [...] H. M. Kocher, M. Capasso

 

March 2019, Allergy 
IL-4 receptor α blockade prevents sensitization and alters acute and long-lasting effects of allergen-specific immunotherapy of murine allergic asthma
D. Russkamp, A. Aguilar-Pimentel, [...] C. B. Schmidt-Weber, S. Blank

 

February 2019, Cell Rep.
Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation
G. Garg, A. Muschaweckh, [...] J. Huehn, A. Kallies, T. Korn

 

January 2019, Nat. Neuroscience
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
S. Parhizkar, T. Arzberger, [...] C. Haass

 

January 2019, Neural Plast. 
Immune Challenge Alters Reactivity of Hippocampal Noradrenergic System in Prenatally Stressed Aged Mice
G. Grigoryan, N. Lonnemann, M. Korte

 

November 2018, Prog Biophys Mol Biol.
PK/PD-based adaptive tailoring of oseltamivir doses to treat within-host influenza viral infections
G. Montaseri, A. Boianelli,  Hernandez-Vargas E.A., M. Meyer-Hermann 

 

November 2018, Brain Behav. Immun.
Microglia have a protective role in viral encephalitis-induced seizure development and hippocampal damage
I. Waltl, C. Käufer, [...] U. Kalinke, W. Löscher

 

October 2018, Front. Cell. Neurosci.
IFN-g producing Th1 cells induce different transcriptional profiles in microglia and astrocytes
K. P. Chittappen, O. Dittrich-Breiholz, S.R. Talbot, P.A. Robert, J. Huehn, M. Stangel 

 

October 2018, Cell Rep.
Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Regulation during Viral Encephalitis
C. Chhatbar, C. N. Detje, [...] M. Stangel, U. Kalinke 

 

October 2018, Nat. Commun.
The olfactory epithelium as a port of entry in neonatal neurolisteriosis
D. Pägelow, C. Chhatbar, [...] U. Kalinke, [...] M. W. Hornef, M. Fulde 

 

September 2018, Front Immunol.
Computer Simulation of Multi-Color Brainbow Staining and Clonal Evolution of B Cells in Germinal Centers
M. Meyer-Hermann, C. Binder, L. Mesin, G.D. Victora

 

September 2018, PNAS
Chemokine receptors CCR2 and CX3CR1 regulate viral encephalitis-induced hippocampal damage but not seizures
C. Käufer, C. Chhatbar, [...] U. Kalinke, W. Löscher

 

August 2018, Plos Pathog.
Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice
W. Koestner, J. Spanier, [...] F. Wacker, U. Kalinke

 

July 2018, Nat. Med.
Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate
L. Bunse, S. Pusch, [...] W. Wick, M. Platten

 

April 2018, J. Hepatol.
Type I Interferon Receptor Signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis
K: Borst, T. Frenz, [...] M. Heikenwaelder, G. Sutter, U. Kalinke

immune-system-1132182_1920

Funding period

Nov. 2017 – Dec. 2021

 

Funding amount

6,000,000 € from the Initiative and Networking Fund of the Helmholtz Association

5,000,000 € co-funding by the Research Centers

 

Participating Helmholtz Centers

German Cancer Research Center (DKFZ)
German Center for Neurodegenerative Diseases (DZNE)
Helmholtz Center Munich (HMGU)
Helmholtz Center for Infection Research (HZI)
Max Delbrück Center for Molecular Medicine (MDC)

 

Coordination

MDC

 

Governing Body

Klaus Rajewsky (MDC)
Michela Di Virgilio (MDC)
Mathias Heikenwälder (DKFZ)
Michael Heneka (DZNE)
Ulrich Kalinke (HZI)
Claudia Traidl-Hoffmann (HMGU)

 

Contact

 

Governing Body

Michela Di Virgilio
Michela.DiVirgilio@mdc-berlin.de

Klaus Rajewsky
Klaus.Rajewsky@mdc-berlin.de


Coordination

Charlotte Quirin
Charlotte.Quirin@mdc-berlin.de
+49 30 9406 1648

Nadja Oellrich
Nadja.Oellrich@mdc-berlin.de

 

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