MDC Lab Coats

Janz/Mathas Lab

Biology of Malignant Lymphomas

Profile

A detailed molecular understanding of the oncogenic process is fundamental for the development of new therapeutic strategies for human lymphomas.

Using cell and molecular biology techniques, high-throughput approaches as well as in vivo mouse models, we aim to gain insight into the network of oncogenic defects in transformed B and T cells.

In particular, we are interested in the link between deregulated signaling and transcription factor activities, disruption of cellular differentiation and oncogenic transformation. Using primarily classical Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL) as model systems, we analyze the role of lineage infidelity, cellular reprogramming and activation of lineage-inappropriate survival signals in lymphomagenesis, as exemplified by our work on the transcription factor E2A, which is essential for the development of B and T lymphoid cells, or aberrant expression of CSF1R, a myeloid-specific growth and survival factor, in lymphoid malignancies.

In addition to studying lymphoma cell autonomous processes, we focus on the elucidation of lymphoma - stroma interactions. Along these lines, we are dissecting signaling networks by chemokines and cytokines that provide essential growth and survival signals for B cell lymphomas. Collectively, our work does not only address fundamental aspects of leukemia and lymphoma pathogenesis, but also aims at providing therapeutic solutions.

Team

Publications

Jobs

Motivated students, PhD and Post-Doc candidates interested in our work are welcome to make informal inquiries at any time.

Profile Image · Mathas/Janz
Dr. Martin Janz
Dr. Stephan Mathas
Group Leaders
Contacts
 
Dr. Martin Janz
(030) 9406 3244
31.1: Max Delbrück House
Room 1034

 

 

Dr. Stephan Mathas
(030) 9406 2720
31.1: Max Delbrück House
Room 1035

 

 

Max-Delbrück-Centrum für Molekulare Medizin (MDC)
Robert-Rössle-Str. 10
13092 Berlin, Germany