An interdisciplinary approach to characterize peanut-allergic patients - first data from the FOOD@ consortium


  • M. Worm
  • A. Alexiou
  • V. Höfer
  • T. Birkner
  • A.C.S.N. Jeanrenaud
  • F. Fauchère
  • K. Pazur
  • C. Steinert
  • A. Arnau-Soler
  • P. Banerjee
  • A. Diefenbach
  • J. Dobbertin-Welsch
  • S. Dölle-Bierke
  • W. Francuzik
  • A. Ghauri
  • S. Heller
  • B. Kalb
  • U. Löber
  • I. Marenholz
  • L. Markó
  • J. Scheffel
  • O. Potapenko
  • St. Roll
  • S. Lau
  • Y.A. Lee
  • J. Braun
  • A. Thiel
  • M. Babina
  • S. Altrichter
  • S.K. Forslund
  • K. Beyer


  • Clinical and Translational Allergy


  • Clin Transl Allergy 12 (10): e12197


  • BACKGROUND: Peanut allergy is a frequent cause of food allergy and potentially life-threatening. Within this interdisciplinary research approach, we aim to unravel the complex mechanisms of peanut allergy. As a first step were applied in an exploratory manner the analysis of peanut allergic versus non-allergic controls. METHODS: Biosamples were studied regarding DNA methylation signatures, gut microbiome, adaptive and innate immune cell populations, soluble signaling molecules and allergen-reactive antibody specificities. We applied a scalable systems medicine computational workflow to the assembled data. RESULTS: We identified combined cellular and soluble biomarker signatures that stratify donors into peanut-allergic and non-allergic with high specificity. DNA methylation profiling revealed various genes of interest and stool microbiota differences in bacteria abundances. CONCLUSION: By extending our findings to a larger set of patients (e.g., children vs. adults), we will establish predictors for food allergy and tolerance and translate these as for example, indicators for interventional studies.