Metabolische Regulation des Blutgefäßwachstums [Metabolic regulation of blood vessel growth]

Recent insights into fundamental aspects of angiogenesis move meta-bolism into the spotlight and highlight the importance of endothelial metabolic adaptation for vascular growth. This notion stems from the realization that endothelial cells (ECs) have to meet the metabolic demands of migration and proliferation when they switch from quiescence to vessel growth. Here we discuss how ECs adapt their metabolism during the angiogenic switch and how the forkhead transcription factor FOXO1 regulates this process.