A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire
Autor/innen
- J. Dobeš
- F. Edenhofer
- M. Vobořil
- T. Brabec
- M. Dobešová
- A. Čepková
- L. Klein
- K. Rajewsky
- D. Filipp
Journal
- European Journal of Immunology
Quellenangabe
- Eur J Immunol 48 (3): 546-548
Zusammenfassung
Medullary thymic epithelial cell (mTEC)-restricted expression of autoimmune regulator (Aire) is essential for establishment of immune tolerance. Recently, Aire was also shown to be expressed in cells of hematopietic and reproductive lineages. Thus, the generation of Aire(fl/fl) mouse strain enables the investigation of the cell-specific function of Aire.