RNA Biology and Posttranscriptional Regulation

Head of the Group

Dr. Markus Landthaler

87: Timoféeff-Ressovsky-House (Genomcentrum)

Room 1.15

Tel. 3026

Fax. 3068

Contact


Secretariat

Sabrina Deter

87: Timoféeff-Ressovsky-House (Genomcentrum)

Room 1.17

Tel. 2920

Fax. 49171

Contact


 

 

 

 

Our main interest is the understanding of post-transcriptional regulatory networks that control gene expression. Post-transcriptional regulation is highly versatile and adaptable in exploiting cellular time and space. microRNAs and RNA-binding proteins play a key role in the regulation of spatial and temporal changes in protein synthesis through control of mRNA transport, storage and translation. Deregulation and failed coordination of these mechanisms contribute to the pathophysiological development and conditions. A prerequisite for a systems level understanding of post-transcriptional regulation is a transcriptome-wide high-resolution map of RNA-protein contacts that allows us to study how these interactions control the fate of mRNAs.

 

 

 

 

picture of Landthaler lab