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MDC Lecture: Mapping the cells of the human heart

Analyzing more than 500,000 human heart cells to help build the most detailed map to date of the human heart – Sarah Teichmann, who heads the Cellular Genetics Programme at the Wellcome Sanger Institute, will share insights during a lecture at the MDC on February 13.

Sarah Teichmann gives a MDC Lecture on February 13.

As one of the leaders of the Human Cell Atlas, Dr Sarah Teichmann will give a lecture at the Berlin Institute of Medical Systems Biology (BIMSB), which is a part of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC). On February 13 she talks about her collaborative work with Professor Norbert Hübner, head of the Genetics and Genomics of Cardiovascular Diseases group at the MDC and Jonathan Seidman, the Bugher Professor of Cardiovascular Genetics at Harvard Medical School. 

38 seed networks work on the Human Cell Atlas – an ambitious global initiative to create a comprehensive reference map of all human cells, which can then be used to better understand health, disease and potential treatment targets. This is especially important for the heart.  

A common seed network

This UMAP shows the different cell types of the heart: cardiomyocytes, fibroblasts, endothelial cells, pericytes, smooth muscle cells, lymphoids, myeloids, neuronal cells and adipocytes. Each dot represents a cell detected across the six different regions of the heart, colors represent cell types.

Teichmann, Hübner and Seidman assembled a team of 13 world’s leading scientist from Germany, the United Kingdom and the United States, dedicated to understanding the human heart cell by cell. Cardiovascular diseases are the leading cause of death worldwide, with an estimated 18 million deaths per year globally. To address this important public health problem and develop novel therapies it is necessary to further understanding of the cellular composition of the heart. 

Scientists from the Seed Network have sampled over 500,000 cells from six regions of the heart, provided by 14 healthy female and male donors. Using large scale single cell omics and state-of-the-art machine learning techniques, the researchers unveiled the cellular composition and regional heterogeneity of this never-resting organ.  

The results presented by Teichmann on February 13, are revealing large differences between cells from different sections of the heart, as well as previously unknown cardiac cell states and transcriptional circuits. During her lecture on “Cell states and transcriptional programmes in the adult human heart” at the MDC Teichmann will discuss these findings and how they change in disease.  

Text: Laura Petersen

MDC Lecture with Sarah Teichmann 

Thursday, February 13, 2:00 pm 

Hannoversche Str. 28 
BIMSB Large Conference Room 
10115 Berlin 
Germany 

No registration required. 

 

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