Basic Research

Jana Kroll, Christian Rosenmund and their teams have captured the fleeting moment a nerve cell releases its neurotransmitters into the synaptic cleft. The work was published in “Nature Communications.”

U.K.-based Wellcome has awarded over €2 million to an international research effort to uncover how malaria can injure developing babies. Emanuel Wyler at the Max Delbrück Center will play a key role in studying the molecular interaction between the parasite Plasmodium falciparum and the placenta.

Markus Mittnenzweig of the Max Delbrück Center has been awarded a €1.5 million grant from the European Research Council. He and his team will build dynamic 3D models of how neighboring cells and gene activity guide early-stage embryonic zebrafish cells to become specialized tissues.

As embryos develop, countless molecular mechanisms interact in intricate ways. Markus Mittnenzweig builds computational models to help decipher and predict the complex processes behind cell differentiation and tissue formation. His work could also contribute to preventing disease.

Michael Robson has won two new grants from the DFG and the Human Frontier Science Program totaling over €2 million. He and his lab are now working to decode the mechanics of chromatin, hoping to finally define its physical state and better understand how it governs gene regulation.

Jan Philipp Junker’s new full professorship at Charité Universitätsmedizin Berlin will enable him to push the boundaries of tissue regeneration research. Using single-cell sequencing, microscopy and genetics, he hopes to unlock ways to enhance organ regeneration in mammals.

Nella Christie Delva joins the lab of Annette Hammes-Lewin’s as a Fulbright scholar. Over the next few months, she will study how environmental stressors cause genetic and neural changes in the brain during development, which can lead to mental health disorders.

Researchers at the Max Delbrück Center have used cryo-electron tomography to uncover new details of the molecular structure of synaptic vesicles, which help transport neurotransmitters in the brain. The study, published in “PNAS,” could inform therapeutic strategies for psychiatric disorders.

As Scientific Director of Max Delbrück Center, Maike Sander is driving a bold shift toward interdisciplinary research to address the health challenges of our time. As a diabetes researcher, her next frontier is to use organ-on-a-chip technologies to build more accurate models of the human pancreas.

Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité – Universitätsmedizin Berlin have elucidated the role of the p53 gene in ulcerative colitis. The study, published in “Science Advances,” suggests a potential new drug target to stop disease progression to cancer.