Daumke Lab

Daumke Lab

Structural Biology of Membrane-Associated Processes

GTPases of the dynamin and septin superfamilies are molecular machines that assemble at the surface of cellular membranes.

Some of these proteins act as dynamic scaffolds that remodel the underlying membrane in a GTPase-dependent fashion; others orchestrate the recruitment of interaction partner in a temporally and spatially defined manner.

We are interested to understand principles of assembly, function and regulation of these GTPases. To this end, structural studies are combined with biochemical and cell-based approaches.

Team

Group Leader

Prof. Dr. Oliver Daumke
Prof. Dr. Oliver Daumke
31.2: Max Delbrück House (Flachbau)
Room: 0225
9406-3425

Scientist

Dr. Tobias Bock-Bierbaum
Dr. Tobias Bock-Bierbaum
31.2: Max Delbrück House (Flachbau)
Room: 0228
030-94063275
Dr. Katja Fälber
Dr. Katja Fälber
31.2: Max Delbrück House (Flachbau)
Room: 0227
3830
Dr. Oleg Ganichkin
Dr. Oleg Ganichkin
31.2: Max Delbrück House (Flachbau)
Room: 0228
+49 30 9406 3275
Dr. Ivan Haralampiev
31.2: Max Delbrück House (Flachbau)
Room: 0228
030/94063275
Dr. Claudia Matthäus
Dr. Claudia Matthäus
31.2: Max Delbrück House (Flachbau)
Room: 0228
9406-3275
Dr. Jeffrey Noel
Dr. Jeffrey Noel
http://smog-server.org/noel
Dr. Yvette Roske
Dr. Yvette Roske
31.2: Max Delbrück House (Flachbau)
Room: 0203
2949
Dr. Thiemo Sprink
Dr. Thiemo Sprink
31.2: Max Delbrück House (Flachbau)
Room: 0223
+49 30 9406 2772

Secretariat

Birgit Cloos
31.2: Max Delbrück House (Flachbau)
Room: 0206
9406-2270

Technical Assistants

Carola Bernert
31.2: Max Delbrück House (Flachbau)
Room: 0277
+49 30 9406-2862
Jeanette Schlegel
31.2: Max Delbrück House (Flachbau)
Room: 0265
3280

PhD student

Kathrin Funck
Kathrin Funck
31.2: Max Delbrück House (Flachbau)
Room: 0226
9406-3139
Stephan Grunwald
31.2: Max Delbrück House (Flachbau)
Room: 0228
3275
Mohd Saif
31.2: Max Delbrück House (Flachbau)
Room: 0226
3139
Marie Witt
31.2: Max Delbrück House (Flachbau)
Room: 0226
0049-30-94063139
Audrey Helena Xavier
31.2: Max Delbrück House (Flachbau)
Room: 0226

Graduate and Undergraduate

Linus Hopf
Linus Hopf

Publications

in J Cell Sci

A SEPT1-based scaffold is required for Golgi integrity and function

K. Song et al.
in Blood

Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma

L. von Hoff et al.
in BIOspektrum

Struktur und Funktion des mechanochemischen Motorproteins Dynamin

K. Faelber et al.
in Proc Natl Acad Sci U S A

Atomistic simulations indicate the functional loop-to-coiled-coil transition in influenza hemagglutinin is not downhill

X. Lin et al.
in Nat Commun

Structural basis for membrane tethering by a bacterial dynamin-like pair

J. Liu et al.
in J Biol Chem

Effects of allelic variations in the human myxovirus resistance protein A on its antiviral activity

L. Graf et al.
in PLoS ONE

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells

K. Schrade et al.
in J Phys Chem B

Anisotropic fluctuations in the ribosome determine tRNA kinetics

H. Yang et al.
in Biophys J

Molecular simulations suggest a force-dependent mechanism of vinculin activation

L. Sun et al.
in Sci Rep

Cryo-EM studies of Drp1 reveal cardiolipin interactions that activate the helical oligomer

C.A. Francy et al.

News

Phd Prize 2017
Science

Philipp Wahle awarded MDC PhD Prize of 2017

Philipp Wahle of the lab of Robert Zinzen developed a highly resolved virtual model of a fly embryo, which shows which genes are active in which cell. He received the MDC PhD Prize at the annual Graduate Ceremony on November 24, 2017 for the paper in which he published these results. Two second-place publications were awarded a prize for the first time.
Institute & Campus

A week in a scientist's shoes: Pupils visit MDC labs

Eric Niller and Pirmin Schmid won a special prize in the youth science competition “Jugend forscht”: they have now spent a week gaining work experience in two research groups at the MDC. There are plenty of opportunities at the MDC for larger school groups, too. The institute runs various events to spark young people’s enthusiasm for the life sciences.
Science By Russell Hodge

The art of folding mitochondrial membranes

Oliver Daumke's lab figures out how the inner membranes of mitochondria "get their groove" and assume the complex shapes they need to carry out crucial cellular functions
Cristae
Press Release No. 12 Berlin

The art of folding mitochondrial membranes

About two billion years ago, foreign bacteria invaded the ancestor of a cell and took up permanent...
Science By Dr. Martin Ballaschk

How proteins reshape cell membranes

Small “bubbles” frequently form on membranes of cells and are taken up into their interior. The process involves EHD proteins – a focus of research by Oliver Daumke of the MDC. He and his team have now shed light on how these proteins assemble on the surface of a cell and reshape its membrane.
Science

Bent to the task: New dynamin structure reveals how it wraps around membranes

Researchers in Berlin and Hannover have published a new structure of the protein dynamin in the...
Science By Russell Hodge

Scrambling a virus

Building a complex machine requires collecting all the parts and putting them together in a precise...
Prof. Dr. Oliver Daumke
Prof. Dr. Oliver Daumke
Contact
Phone: 9406-3425
Max-Delbrück-Centrum für Molekulare Medizin (MDC)
Robert-Rössle-Str. 10
13092 Berlin, Deutschland
Building 31.2, Room 0225

Research Topics