Daumke Lab

Daumke Lab

Structural Biology of Membrane-Associated Processes

GTPases of the dynamin and septin superfamilies are molecular machines that assemble at the surface of cellular membranes.

Some of these proteins act as dynamic scaffolds that remodel the underlying membrane in a GTPase-dependent fashion; others orchestrate the recruitment of interaction partner in a temporally and spatially defined manner.

We are interested to understand principles of assembly, function and regulation of these GTPases. To this end, structural studies are combined with biochemical and cell-based approaches.

Team

Group Leader

Prof. Dr. Oliver Daumke
Prof. Dr. Oliver Daumke
31.2: Max-Delbrück-Haus
Room: 0225
+49 30 9406-3425

Scientist

Dr. Tobias Bock-Bierbaum
Dr. Tobias Bock-Bierbaum
31.2: Max-Delbrück-Haus
Room: 0228
+49 30 9406-3275
Dr. Katja Fälber
Dr. Katja Fälber
31.2: Max-Delbrück-Haus
Room: 0227
+49 30 9406-3830
Dr. Ivan Haralampiev
Dr. Ivan Haralampiev
31.2: Max-Delbrück-Haus
Room: 0228
+49 30 9406-3275
Dr. Yvette Roske
Dr. Yvette Roske
31.2: Max-Delbrück-Haus
Room: 0203
+49 30 9406-2949

Secretariat

Birgit Cloos
31.2: Max-Delbrück-Haus
Room: 0206
+49 30 9406-2270

Technical Assistants

Carola Bernert
31.2: Max-Delbrück-Haus
Room: 0278
+49 30 9406-2862
Jeanette Schlegel
Jeanette Schlegel
31.2: Max-Delbrück-Haus
Room: 0265
+49 30 9406-3280

PhD student

Kathrin Funck
Kathrin Funck
31.2: Max-Delbrück-Haus
Room: 0226
+49 30 9406-3139
Paul Ferdinand Krupp
31.2: Max-Delbrück-Haus
Room: 0222
+49 30 9406-3496
Mohd Saif
Mohd Saif
31.2: Max-Delbrück-Haus
Room: 0226
+49 30 9406-3139
Elena Vazquez Sarandeses
Elena Vazquez Sarandeses
31.2: Max-Delbrück-Haus
Room: 0223
Audrey Helena Xavier
31.2: Max-Delbrück-Haus
Room: 0226

Publications

in Nat Commun

Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates

  • S. Grunwald
  • L.V.M. Hopf
  • T. Bock-Bierbaum
  • C.C.M. Lally
  • C.M.T. Spahn
  • O. Daumke
in Lancet Neurol

Monogenic variants in dystonia: an exome-wide sequencing study

  • M. Zech
  • R. Jech
  • S. Boesch
  • M. Škorvánek
  • S. Weber
  • M. Wagner
  • C. Zhao
  • A. Jochim
  • J. Necpál
  • Y. Dincer
  • K. Vill
  • F. Distelmaier
  • M. Stoklosa
  • M. Krenn
  • S. Grunwald
  • T. Bock-Bierbaum
  • A. Fečíková
  • P. Havránková
  • J. Roth
  • I. Příhodová
  • M. Adamovičová
  • O. Ulmanová
  • K. Bechyně
  • P. Danhofer
  • B. Veselý
  • V. Haň
  • P. Pavelekova
  • Z. Gdovinová
  • T. Mantel
  • T. Meindl
  • A. Sitzberger
  • S. Schröder
  • A. Blaschek
  • T. Roser
  • M.V. Bonfert
  • E. Haberlandt
  • B. Plecko
  • B. Leineweber
  • S. Berweck
  • T. Herberhold
  • B. Langguth
  • J. Švantnerová
  • M. Minár
  • G.A. Ramos-Rivera
  • M.H. Wojcik
  • S. Pajusalu
  • K. Õunap
  • U.A. Schatz
  • L. Pölsler
  • I. Milenkovic
  • F. Laccone
  • V. Pilshofer
  • R. Colombo
  • S. Patzer
  • A. Iuso
  • J. Vera
  • M. Troncoso
  • F. Fang
  • H. Prokisch
  • F. Wilbert
  • M. Eckenweiler
  • E. Graf
  • D.S. Westphal
  • K.M. Riedhammer
  • T. Brunet
  • B. Alhaddad
  • R. Berutti
  • T.M. Strom
  • M. Hecht
  • M. Baumann
  • M. Wolf
  • A. Telegrafi
  • R.E. Person
  • F.M. Zamora
  • L.B. Henderson
  • D. Weise
  • T. Musacchio
  • J. Volkmann
  • A. Szuto
  • J. Becker
  • K. Cremer
  • T. Sycha
  • F. Zimprich
  • V. Kraus
  • C. Makowski
  • P. Gonzalez-Alegre
  • T.M. Bardakjian
  • L.J. Ozelius
  • A. Vetro
  • R. Guerrini
  • E. Maier
  • I. Borggraefe
  • A. Kuster
  • S.B. Wortmann
  • A. Hackenberg
  • R. Steinfeld
  • B. Assmann
  • C. Staufner
  • T. Opladen
  • E. Růžička
  • R.D. Cohn
  • D. Dyment
  • W.K. Chung
  • H. Engels
  • A. Ceballos-Baumann
  • R. Ploski
  • O. Daumke
  • B. Haslinger
  • V. Mall
  • K. Oexle
  • J. Winkelmann
in Cell Rep

hGBP1 coordinates chlamydia restriction and inflammasome activation through sequential GTP hydrolysis

  • A. Xavier
  • M.A. Al-Zeer
  • T.F. Meyer
  • O. Daumke
in J Mol Biol

The pierced lasso topology leptin has a bolt on dynamic domain composed by the disordered loops I and III

  • J. Danielsson
  • J.K. Noel
  • J.M. Simien
  • B.M. Duggan
  • M. Oliveberg
  • J.N. Onuchic
  • P.A. Jennings
  • E. Haglund
in Aging Cell

Age attenuates the T-type Ca(V) 3.2-RyR axis in vascular smooth muscle

  • G. Fan
  • M. Kaßmann
  • Y. Cui
  • C. Matthaeus
  • S. Kunz
  • C. Zhong
  • S. Zhu
  • Yu Xie
  • D. Tsvetkov
  • O. Daumke
  • Yu Huang
  • M. Gollasch
in Proc Natl Acad Sci U S A

EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake

  • C. Matthaeus
  • I. Lahmann
  • S. Kunz
  • W. Jonas
  • A.A. Melo
  • M. Lehmann
  • E. Larsson
  • R. Lundmark
  • M. Kern
  • M. Blüher
  • H. Olschowski
  • J. Kompa
  • B. Brügger
  • D.N. Müller
  • V. Haucke
  • A. Schürmann
  • C. Birchmeier
  • O. Daumke
in Biophys J

Polymer-like model to study the dynamics of dynamin filaments on deformable membrane tubes

  • J.K. Noel
  • F. Noé
  • O. Daumke
  • A.S. Mikhailov
in PLoS ONE

eNOS-NO-induced small blood vessel relaxation requires EHD2-dependent caveolae stabilization

  • C. Matthaeus
  • X. Lian
  • S. Kunz
  • M. Lehmann
  • C. Zhong
  • C. Bernert
  • I. Lahmann
  • D.N. Müller
  • M. Gollasch
  • O. Daumke
in Cell Rep

53BP1 supports immunoglobulin class switch recombination independently of its DNA double-strand break end protection function

  • D. Sundaravinayagam
  • A. Rahjouei
  • M. Andreani
  • D. Tupiņa
  • S. Balasubramanian
  • T. Saha
  • V. Delgado-Benito
  • V. Coralluzzo
  • O. Daumke
  • M. Di Virgilio
in Autophagy

How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates

  • E. Turco
  • M. Witt
  • C. Abert
  • T. Bock-Bierbaum
  • M.Y. Su
  • R. Trapannone
  • M. Sztacho
  • A. Danieli
  • X. Shi
  • G. Zaffagnini
  • A. Gamper
  • M. Schuschnig
  • D. Fracchiolla
  • D. Bernklau
  • J. Romanov
  • M. Hartl
  • J.H. Hurley
  • O. Daumke
  • S. Martens

News

Kristall
Science

Getting to the heart of an enzyme

A team led by Oliver Daumke at the MDC has determined the three-dimensional structure of the NatC acetyltransferase in an article published in Nature Communications. This enzyme modifies cell proteins to enable them to perform their functions correctly. In cancer cells, however, NatC is often overactive.
header
Science By Christina Anders

Cells sound the alarm on chlamydia

A chlamydia infection triggers an inflammatory response at the cellular level. MDC researchers conducted experiments in cell cultures to examine the role that the enzyme GBP1 plays in this response. They have now published their findings in Cell Reports.
Lipidtropfen Fettzelle Adipocyte
Press Release No. 12 Berlin

Protein controls fat metabolism

A protein in the cell envelope influences the rate of fatty acid uptake in cells. This is reported by MDC researchers in the journal PNAS. This process also appears to be altered in overweight people.
Kryo Haus
Institute & Campus By Christina Anders

Buch campus to get ultralow temperature microscopes

By mid-2020 two new cryogenic electron microscopes (cryo-EM) will be available to scientists at the Buch campus. The building is almost finished, and the first crates of equipment were delivered in December. There’s still a lot to do, however, before everything is up and running.
PM Daumke Mitochondrien
Press Release No. 35 Berlin

Keeping a cell’s powerhouse in shape

A German-Swiss team around Professor Oliver Daumke from the MDC has investigated how a protein of the dynamin family deforms the inner mitochondrial membrane. The results, which also shed light on a hereditary disease of the optic nerve, have been published in Nature.
molecule model
Science

How cells devour themselves

Cells sometimes love themselves to pieces – and develop a big appetite for their own components. A group of researchers led by Professor Oliver Daumke of the MDC has now discovered how certain molecules trigger this self-cleaning process.
Spheroid
Science

“It’s important that we explain our research”

The MINT400 Forum in Berlin brings together teachers and schoolchildren from all over Germany. Two researchers from the Max Delbrück Center for Molecular Medicine (MDC) are offering workshops at the networking meeting – partly because one of them was once a teacher himself.
Chris Fröhlich
Institute & Campus By Jana Schlütter

“My magnifying glass has drastically changed”

An interview with MDC alumnus Chris Froehlich, who is currently working as a postdoc at Columbia University in New York City.
Phd Prize 2017
Science

Philipp Wahle awarded MDC PhD Prize of 2017

Philipp Wahle of the lab of Robert Zinzen developed a highly resolved virtual model of a fly embryo, which shows which genes are active in which cell. He received the MDC PhD Prize at the annual Graduate Ceremony on November 24, 2017 for the paper in which he published these results. Two second-place publications were awarded a prize for the first time.
Institute & Campus

A week in a scientist's shoes: Pupils visit MDC labs

Eric Niller and Pirmin Schmid won a special prize in the youth science competition “Jugend forscht”: they have now spent a week gaining work experience in two research groups at the MDC. There are plenty of opportunities at the MDC for larger school groups, too. The institute runs various events to spark young people’s enthusiasm for the life sciences.
Prof. Dr. Oliver Daumke
Prof. Dr. Oliver Daumke
Contact
Phone: +49 30 9406-3425
Max-Delbrück-Centrum für Molekulare Medizin (MDC)
Robert-Rössle-Straße 10
13125 Berlin, Deutschland
Building 31.2, Room 0225

Research Topics