Daumke Lab | MDC Berlin

GTPases of the dynamin and septin superfamilies are molecular machines that assemble at the surface of cellular membranes.

Some of these proteins act as dynamic scaffolds that remodel the underlying membrane in a GTPase-dependent fashion; others orchestrate the recruitment of interaction partner in a temporally and spatially defined manner.

We are interested to understand principles of assembly, function and regulation of these GTPases. To this end, structural studies are combined with biochemical and cell-based approaches.

Group Leader

Prof. Dr. Oliver Daumke

Prof. Dr. Oliver Daumke

31.2: Max-Delbrück-Haus

oliver.daumke@mdc-berlin.de

+49 30 9406-3425

Scientist

Dr. Tobias Bock-Bierbaum

Dr. Tobias Bock-Bierbaum

31.2: Max-Delbrück-Haus

Tobias.Bock-Bierbaum@mdc-berlin.de

+49 30 9406-3275

Dr. Katja Fälber

Dr. Katja Fälber

31.2: Max-Delbrück-Haus

katja.faelber@mdc-berlin.de

+49 30 9406-3830

Dr. Ivan Haralampiev

Dr. Ivan Haralampiev

31.2: Max-Delbrück-Haus

Ivan.Haralampiev@mdc-berlin.de

+49 30 9406-3275

Paul Ferdinand Krupp

31.2: Max-Delbrück-Haus

PaulFerdinand.Krupp@mdc-berlin.de

+49 30 9406-3496

Dr. Jeffrey Noel

Dr. Jeffrey Noel

Jeffrey.Noel@mdc-berlin.de

Dr. Yvette Roske

Dr. Yvette Roske

31.2: Max-Delbrück-Haus

yroske@mdc-berlin.de

+49 30 9406-2949

Dr. Thiemo Sprink

Dr. Thiemo Sprink

31.2: Max-Delbrück-Haus

Thiemo.Sprink@mdc-berlin.de

+49 30 9406-2772

Dr. Helena Taberman

Dr. Helena Taberman

Helena.Taberman@mdc-berlin.de

Secretariat

31.2: Max-Delbrück-Haus

bcloos@mdc-berlin.de

+49 30 9406-2270

Technical Assistants

31.2: Max-Delbrück-Haus

bernert@mdc-berlin.de

+49 30 9406-2862

Jeanette Schlegel

Jeanette Schlegel

31.2: Max-Delbrück-Haus

Jeanette.Schlegel@mdc-berlin.de

+49 30 9406-3280

PhD student

Paul Carlos Becker

Paul Carlos Becker

PaulCarlos.Becker@mdc-berlin.de

Kathrin Funck

31.2: Max-Delbrück-Haus

Kathrin.Funck@mdc-berlin.de

+49 30 9406-3139

Mohd Saif

31.2: Max-Delbrück-Haus

Mohd.Saif@mdc-berlin.de

+49 30 9406-3139

Elena Vazquez Sarandeses

Elena Vazquez Sarandeses

31.2: Max-Delbrück-Haus

Elena.Vazquez@mdc-berlin.de

Audrey Helena Xavier

31.2: Max-Delbrück-Haus

AudreyHelena.Xavier@mdc-berlin.de

Projects

A short overview on our projects on dynamin superfamily proteins (dynamin, DNM1L, MxA), GIMAPs, and stomatin proteins is shown in the corresponding sections.

Dynamin 1-like Protein (DNM1L)

Eps15-homology domain containing proteins (EHDs)

GTPases of the Immunity associated proteins (GIMAPs)

Myxovirus-resistance proteins

Stomatin proteins

November 01, 2020 in Lancet Neurol

Monogenic variants in dystonia: an exome-wide sequencing study

May 19, 2020 in Cell Rep

hGBP1 coordinates chlamydia restriction and inflammasome activation through sequential GTP hydrolysis

A. Xavier
M.A. Al-Zeer
T.F. Meyer
O. Daumke

April 17, 2020 in J Mol Biol

The pierced lasso topology leptin has a bolt on dynamic domain composed by the disordered loops I and III

J. Danielsson
J.K. Noel
J.M. Simien
B.M. Duggan
M. Oliveberg
J.N. Onuchic
P.A. Jennings
E. Haglund

April 01, 2020 in Aging Cell

Age attenuates the T-type Ca(V) 3.2-RyR axis in vascular smooth muscle

G. Fan
M. Kaßmann
Y. Cui
C. Matthaeus
S. Kunz
C. Zhong
S. Zhu
Yu Xie
D. Tsvetkov
O. Daumke
Yu Huang
M. Gollasch

March 31, 2020 in Proc Natl Acad Sci U S A

EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake

C. Matthaeus
I. Lahmann
S. Kunz
W. Jonas
A.A. Melo
M. Lehmann
E. Larsson
R. Lundmark
M. Kern
M. Blüher
H. Olschowski
J. Kompa
B. Brügger
D.N. Müller
V. Haucke
A. Schürmann
C. Birchmeier
O. Daumke

November 19, 2019 in Biophys J

Polymer-like model to study the dynamics of dynamin filaments on deformable membrane tubes

J.K. Noel
F. Noé
O. Daumke
A.S. Mikhailov

October 10, 2019 in PLoS ONE

eNOS-NO-induced small blood vessel relaxation requires EHD2-dependent caveolae stabilization

C. Matthaeus
X. Lian
S. Kunz
M. Lehmann
C. Zhong
C. Bernert
I. Lahmann
D.N. Müller
M. Gollasch
O. Daumke

August 06, 2019 in Cell Rep

53BP1 supports immunoglobulin class switch recombination independently of its DNA double-strand break end protection function

D. Sundaravinayagam
A. Rahjouei
M. Andreani
D. Tupiņa
S. Balasubramanian
T. Saha
V. Delgado-Benito
V. Coralluzzo
O. Daumke
M. Di Virgilio

August 01, 2019 in Autophagy

How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates

E. Turco
M. Witt
C. Abert
T. Bock-Bierbaum
M.Y. Su
R. Trapannone
M. Sztacho
A. Danieli
X. Shi
G. Zaffagnini
A. Gamper
M. Schuschnig
D. Fracchiolla
D. Bernklau
J. Romanov
M. Hartl
J.H. Hurley
O. Daumke
S. Martens

July 18, 2019 in Nature

Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1

K. Faelber
L. Dietrich
J.K. Noel
F. Wollweber
A.K. Pfitzner
A. Mühleip
R. Sánchez
M. Kudryashev
N. Chiaruttini
H. Lilie
J. Schlegel
E. Rosenbaum
M. Hessenberger
C. Matthaeus
S. Kunz
A. von der Malsburg
F. Noé
A. Roux
M. van der Laan
W. Kühlbrandt
O. Daumke

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Science May 19, 2020 By Christina Anders

Cells sound the alarm on chlamydia

A chlamydia infection triggers an inflammatory response at the cellular level. MDC researchers conducted experiments in cell cultures to examine the role that the enzyme GBP1 plays in this response. They have now published their findings in Cell Reports.

Lipidtropfen Fettzelle Adipocyte

Press Release No. 12 March 16, 2020 Berlin

Protein controls fat metabolism

A protein in the cell envelope influences the rate of fatty acid uptake in cells. This is reported by MDC researchers in the journal PNAS. This process also appears to be altered in overweight people.

Kryo Haus

Institute & Campus January 23, 2020 By Christina Anders

Buch campus to get ultralow temperature microscopes

By mid-2020 two new cryogenic electron microscopes (cryo-EM) will be available to scientists at the Buch campus. The building is almost finished, and the first crates of equipment were delivered in December. There’s still a lot to do, however, before everything is up and running.

PM Daumke Mitochondrien

Press Release No. 35 July 10, 2019 Berlin

Keeping a cell’s powerhouse in shape

A German-Swiss team around Professor Oliver Daumke from the MDC has investigated how a protein of the dynamin family deforms the inner mitochondrial membrane. The results, which also shed light on a hereditary disease of the optic nerve, have been published in Nature.

molecule model

Science June 13, 2019

How cells devour themselves

Cells sometimes love themselves to pieces – and develop a big appetite for their own components. A group of researchers led by Professor Oliver Daumke of the MDC has now discovered how certain molecules trigger this self-cleaning process.

Spheroid

Science February 19, 2019

“It’s important that we explain our research”

The MINT400 Forum in Berlin brings together teachers and schoolchildren from all over Germany. Two researchers from the Max Delbrück Center for Molecular Medicine (MDC) are offering workshops at the networking meeting – partly because one of them was once a teacher himself.

Chris Fröhlich

Institute & Campus January 24, 2018 By Jana Schlütter

“My magnifying glass has drastically changed”

An interview with MDC alumnus Chris Froehlich, who is currently working as a postdoc at Columbia University in New York City.

Phd Prize 2017

Science December 08, 2017

Philipp Wahle awarded MDC PhD Prize of 2017

Philipp Wahle of the lab of Robert Zinzen developed a highly resolved virtual model of a fly embryo, which shows which genes are active in which cell. He received the MDC PhD Prize at the annual Graduate Ceremony on November 24, 2017 for the paper in which he published these results. Two second-place publications were awarded a prize for the first time.

Institute & Campus July 21, 2017

A week in a scientist's shoes: Pupils visit MDC labs

Eric Niller and Pirmin Schmid won a special prize in the youth science competition “Jugend forscht”: they have now spent a week gaining work experience in two research groups at the MDC. There are plenty of opportunities at the MDC for larger school groups, too. The institute runs various events to spark young people’s enthusiasm for the life sciences.

Science June 09, 2017 By Russell Hodge

The art of folding mitochondrial membranes

Oliver Daumke's lab figures out how the inner membranes of mitochondria "get their groove" and assume the complex shapes they need to carry out crucial cellular functions

Prof. Dr. Oliver Daumke

Contact

oliver.daumke@mdc-berlin.de

Phone: +49 30 9406-3425

Max-Delbrück-Centrum für Molekulare Medizin (MDC)
Robert-Rössle-Straße 10
13125 Berlin, Deutschland

Building 31.2, Room 0225

Research Topics