Daumke Lab

Daumke Lab

Structural Biology of Membrane-Associated Processes

GTPases of the dynamin and septin superfamilies are molecular machines that assemble at the surface of cellular membranes.

Some of these proteins act as dynamic scaffolds that remodel the underlying membrane in a GTPase-dependent fashion; others orchestrate the recruitment of interaction partner in a temporally and spatially defined manner.

We are interested to understand principles of assembly, function and regulation of these GTPases. To this end, structural studies are combined with biochemical and cell-based approaches.

Team

Group Leader

Prof. Dr. Oliver Daumke
Prof. Dr. Oliver Daumke
31.2: Max Delbrück House (Flachbau)
Room: 0225
9406-3425

Scientist

Dr. Tobias Bock
31.2: Max Delbrück House (Flachbau)
Room: 0228
030-94063275
Dr. Katja Fälber
31.2: Max Delbrück House (Flachbau)
Room: 0227
3830
Dr. Oleg Ganichkin
31.2: Max Delbrück House (Flachbau)
Room: 0228
+49 30 9406 3275
Dr. Claudia Matthäus
31.2: Max Delbrück House (Flachbau)
Room: 0228
9406-3275
Dr. Jeffrey Noel
http://smog-server.org/noel
Dr. Thiemo Sprink
31.2: Max Delbrück House (Flachbau)
Room: 0223
+49 30 9406 2772

Secretariat

Birgit Cloos
31.2: Max Delbrück House (Flachbau)
Room: 0206
9406-2270

Technical Assistants

Carola Bernert
31.2: Max Delbrück House (Flachbau)
Room: 0277
9406-2862
9406-3139
Jeanette Schlegel
31.2: Max Delbrück House (Flachbau)
Room: 0265
3280
Sabine Werner
31.2: Max Delbrück House (Flachbau)
Room: 0225
3425

PhD student

Stephan Grunwald
31.2: Max Delbrück House (Flachbau)
Room: 0228
3275
Kathrin Lipka
31.2: Max Delbrück House (Flachbau)
Room: 0226
9406-3139
Mohd Saif
31.2: Max Delbrück House (Flachbau)
Room: 0226
3139
Marie Witt
31.2: Max Delbrück House (Flachbau)
Room: 0226
0049-30-94063139
Audrey Helena Xavier
31.2: Max Delbrück House (Flachbau)
Room: 0226

Publications

in J Biol Chem

Effects of allelic variations in the human myxovirus resistance protein A on its antiviral activity

L. Graf et al.
in PLoS ONE

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells

K. Schrade et al.
in J Phys Chem B

Anisotropic fluctuations in the ribosome determine tRNA kinetics

H. Yang et al.
in Biophys J

Molecular simulations suggest a force-dependent mechanism of vinculin activation

L. Sun et al.
in Sci Rep

Cryo-EM studies of Drp1 reveal cardiolipin interactions that activate the helical oligomer

C.A. Francy et al.
in Structure

Structural basis for aryl hydrocarbon receptor-mediated gene activation

K.W. Schulte et al.
in Nat Commun

Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctions

M. Hessenberger et al.
in Proc Natl Acad Sci U S A

Structural insights into the activation mechanism of dynamin-like EHD ATPases

A.A. Melo et al.
in Curr Biol

Mitochondrial homeostasis: How do dimers of mitofusins mediate mitochondrial fusion?

O. Daumke et al.
in Sci Rep

Characterization of the CD177 interaction with the ANCA antigen proteinase 3

U. Jerke et al.

News

Prof. Dr. Oliver Daumke
Prof. Dr. Oliver Daumke
Contact
Phone: 9406-3425
Max-Delbrück-Centrum für Molekulare Medizin (MDC)
Robert-Rössle-Str. 10
13092 Berlin, Deutschland
Building 31.2, Room 0225

Research Topics