Nerve cells cultivated from mouse stem cells

Single cell technologies for personalized medicine

Focus area together with the Berlin Institute of Health (BIH)

Single-cell technologies for personalized medicine is a research focus of the Berlin Institute of Health (BIH), Charité - Universitätsmedizin Berlin and Max Delbrück Center. Nikolaus Rajewsky (MDC) coordinates the focus area together with Angelika Eggert (Charité). Single cell analysis is also the basis for the pan-European LifeTime consortium: "Life Time: Revolutionizing Healthcare by Tracking and Understanding Human Cells during Disease".

In order to make the highly innovative single cell technologies clinically usable for effective translation as quickly as possible, BIH is establishing a jointly supported, close interdisciplinary cooperation, in which BIH and Charité will contribute clinic-related expertise (bioinformatics, imaging, machine learning, oncology, neurology, dermatology, biobanks, diagnostics and biomarkers) and the MDC-Mitte (BIMSB) technological and scientific expertise in the field of single cell biology and gene regulation.

The implementation is based on two pillars:

The establishment of four bridge junior research groups from BIH, MDC-Mitte (BIMSB) and Charité, which bring single cell expertise into clinical application. These junior research groups are located in the BIMSB building, where they have access to the latest single cell technologies and are in close contact with leading international scientists*. At the same time, each of these groups is integrated into a clinic at the Charité where they identify clinically relevant topics, use and develop single cell approaches to address specific clinical issues and establish the technologies for clinical use. This bridge concept optimally combines the internationally leading position of the BIMSB in the development of single cell technologies with the clinical-translational potential of BIH/Charité.

The development of a "Clinical Single Cell Sequencing" pipeline, which includes a central bioportal (patient sample collection, characterization and processing) as well as an integrated workflow with relevant genomics and bioinformatics services for the participating clinics.

 

Steering Committee

 

Speaker


Co-Speaker

Prof. Dr. Angelika Eggert
Director Department of Paedriatrics, Department of Oncology and Hematology
Charité – Universitätsmedizin Berlin


Members

Prof. Dr. Frank Heppner
Director Institute of Neuropathology
Charité – Universitätsmedizin Berlin

Prof. Dr. Norbert Hübner
Head of the lab "Genetics and Genomics of Cardiovascular Diseases"
MDC

Dr. Jan Philipp Junker
Head of the lab "Quantitative Developmental Biology"
MDC

Prof. Dr. Ulrich Keilholz
Director Charité Comprehensive Cancer Center (CCCC)
Charité – Universitätsmedizin Berlin

Prof. Dr. Ana Pombo
Head of the lab "Epigenetic Regulation and Chromatin Architecture"
MDC

Prof. Dr. med. Frank Tacke
Department Head, Department of Hepatology and Gastroenterology
Charité – Universitätsmedizin Berlin
 

BIH-CSCS-Pipeline Governance Board

(reporting to the steering committee)

Chair

Prof. Dr. Ulrich Keilholz
Direktor des Charité Comprehensive Cancer Center (CCCC)
Charité – Universitätsmedizin Berlin

Members

Prof. Dr. Angelika Eggert
Director Department of Paedriatrics, Department of Oncology and Hematology
Charité – Universitätsmedizin Berlin

Prof. Dr. Frank Heppner
Director Institute of Neuropathology
Charité – Universitätsmedizin Berlin

Prof. Dr. Ana Pombo
Head of the lab "Epigenetic Regulation and Chromatin Architecture"
MDC

Prof. Dr. Uwe Ohler
Head of the lab "Computational Regulatory Genomics"
MDC

Single-Cell Tech leader (TBA)
MDC
 


Further links and information
 

 

Image: Alessandra Zappulo / Marina Chekulaeva Lab, MDC

 

Contact

Rukeia El-Athman
Scientific Coordinator
Phone: +49 30 450 543 314
E-Mail: rukeia.el-athman@bihealth.de

Dr. Chiara Baccin
Single Cell Project Manager
Berlin Institute for Medical Systems Biology (BIMSB)
Max Delbrück Center for Molecular Medicine (MDC)
Hannoversche Str. 28 | 10115 | Berlin
E-Mail: chiara.baccin@mdc-berlin.de
Phone: +49 (0)30 9406 1380