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Coscia Lab

Spatial Proteomics

Profile

The quantitative analysis of proteins in space and time, the building blocks of life that dictate health and disease, is key to our molecular understanding of severe diseases, such as cancer. Tumors are comprised of multiple cell types and phenotypic cellular states, which are often spatially organized in the complex tissue microenvironment. Studying these diverse cell types and their dynamic interplay on a global, quantitative and unbiased scale, requires novel multimodal concepts on the basis of interdisciplinary, translational research.

Our translational research group develops and applies mass spectrometry (MS) based proteomics workflows for spatially-resolved systems biology. For this purpose, we use a combination of analytical tools including multi-level proteomics (expression-, interaction- phospho-proteomics) and functional cell biology assays.

From left to right: Fabian Coscia, Di Qin, Sonja Fritzsche, Jeannine Engel, Melissa Klingeberg, Janett König, Jose Nimo, Anuar Makhmut

We have recently co-developed Deep Visual Proteomics, a first-of-its-kind concept that combines high-resolution imaging, AI-guided image analysis and ultra-sensitive MS-based proteomics. Applied to preclinical models and archived biobank specimens, this concept allows us to gain unprecedented insights into cellular proteome heterogeneity.  

As part of the Berlin-centered Research Node ‘MSTARS’ (Multimodal clinical mass spectrometry to target treatment resistance), our MDC group closely collaborates with the Berlin Institute of Health, the Max Planck Institute for Molecular Genetics and the Humboldt University and the CHARITÉ. MSTARS, which is funded by the German Ministry of Science and Technology (BMBF) combines a broad range of complementary proteomic, metabolomic and imaging-based technologies with computational approaches for next-level patient care. 

Our long-term vision is to decipher molecular and cellular disease pattern that can be used as predictive measures in precision oncology.

Team

From left to right: Fabian Coscia, Di Qin, Sonja Fritzsche, Jeannine Engel, Melissa Klingeberg, Janett König, Jose Nimo, Anuar Makhmut

 

Group Leader

         Short CV

  • June 2021: Principal Investigator ‘Spatial Proteomics Group’
    Max Delbrück Center for Molecular Medicine, Berlin, Germany.
  • 2017-2021: Post-Doc, Mann lab (Clinical Proteomics)
    University of Copenhagen (NNF Center for Protein Research)
    From 2019: Marie Skłodowska-Curie Postdoctoral Fellow
  • 2012- 2016: PhD candidate (Dr. rer. nat.), Mann lab
    Max Planck Institute of Biochemistry, Munich, Germany
  • 2009-2011: Master of Science Molecular Biotechnology
    TUM Munich, Germany.

PhD student

PhD student

PhD student

PhD student

PhD student

Technical Assistant

Secretariat

 

Publications

News

Lab news

Oct 2023: Our lab's first publication is out in Cell Systems!
Highlights•Detailed protocol and guidelines for ultra-low-input spatial tissue proteomics•Single-cell MS-based proteomics data obtained from archival FFPE tissue•MS signal allows to normalize across tissue types and sample amounts•Cytokines and transcriptional regulators quantified in tonsil microregionsMore info here: https://www.cell.com/cell-systems/fulltext/S2405-4712(23)00287-9

 

Sept 2023: Our lab was awarded an ERC Starting Grant!!!
Please see more info about the project here: https://www.mdc-berlin.de/de/news/press/erc-starting-grant-fuer-fabian-… (English)and here: https://cms2.mdc-berlin.net/de/news/press/erc-starting-grant-fuer-fabia… (German)
Aug 2023: What an achievement for Anuar winning the best short talk award at the Single-Cell Proteomics Conference in Vienna!
Congratulations Anuar! 
​​​​​July 2023: Melissa was awarded the MDC PhD fellowship!
Congrats to Melissa Klingberg, who did her Master's thesis in our lab. She was now awarded a PhD fellowship position for the International PhD Program at the Max Delbrück Center! Congrats Melissa, we are very happy to have you in our group!
May 2023: Our lab's first preprint is online! :-)
Congrats to the entire team and our first author Anuar. We describe a scalable workflow for ultra-low input FFPE tissue proteomics. Our microscopy-guided proteomics approach shows that single-cell analysis from FFPE tissue is principally achievable! A great basis for many biomedical applications in the near future.

More infos here: https://www.biorxiv.org/content/10.1101/2023.05.13.540426v1

 

St Nicholas Mass Spectrometry Symposium 2022​​​​
Our group co-organized a Berlin networking event at the Charité, together with the Ralser, Demichev and Muelleder labs

The event was held on December 8th with over 150 participants from the Berlin area

 

Oct 2022: New group picture
 

 

First lab retreat 2022
One full day of kayaking, swimming and relaxing. Exploring the beautiful nature around Berlin.

 

Jobs