Berlin Institute for Medical Systems Biology (MDC-BIMSB)

BIMSB Groups

Bioinformatics and Omics Data Science

Altuna Akalin

Birol Lab

Single Molecule Biophysics probing Quantitative Neuroscience

Local RNA metabolism in neurons and neurodegeneration

Grosswendt Lab

From Cell States to Function

Haas Lab

Systems Hematology, Stem Cells & Precision Medicine

Haghverdi Lab

Computational methodologies and omic analytics

Junker Lab

Quantitative Developmental Biology

Kaminski Lab

Kidney Cell Engineering

Proteomics and Metabolomics

Stefan Kempa

Metzger Lab

Quantitative Stem Cell Biology

Mittnenzweig Lab

Computational and developmental biology

Landthaler Lab

RNA Biology and Posttranscriptional Regulation

Ludwig Lab

Stem Cell Dynamics and Mitochondrial Genomics

Meyer Lab

Bioinformatics of RNA Structure and Transcriptome Regulation

Ohler Lab

Computational Regulatory Genomics

Pombo Lab

Epigenetic Regulation and Chromatin Architecture

N. Rajewsky Lab

Systems Biology of Gene Regulatory Elements

Robson Lab

Chromatin (dys)function in disease

Organoids

Agnieszka Rybak-Wolf

Genomics Technology platform

Janine Altmüller

Sanders Lab

Genome instability and somatic mosaicism

Sigal Lab

Gastrointestinal Barrier, Regeneration and Carcinogenesis

Systems Biology Imaging

Robert P. Zinzen

BIMSB Associated Groups

Kainmueller Lab

Biomedical Image Analysis

J. Wolf Lab

Mathematical Modelling of Cellular Processes

Selbach Lab

Proteome Dynamics

Piazza Lab

Allosteric Proteomics

Affiliated Groups

Ostendorf Lab

Systems Cancer Immunology

Scientific Technology Platforms

State-of-the-art in-house technology platforms are instrumental to carry out the data intensive research characterizing systems biology. BIMSB Scientific Technology Platforms provide core services, plan projects in close collaboration with both MDC groups and local/international partners, and also conduct research and method development projects, pushing forward novel scientific and in particular medical applications towards personalized medicine.

The BIMSB Scientific Technology Platforms currently offer:

Bioinformatics and Omics Data Science

Altuna Akalin

Genomics Technology platform

Janine Altmüller

Systems Biology Imaging

Robert P. Zinzen

Organoids

Agnieszka Rybak-Wolf

Proteomics and Metabolomics

Stefan Kempa

The Scientific Technology Platforms allow the application of sophisticated, novel and specialized methodologies such as PAR-CLIP (photoactivatable- ribonucleoside- enhanced- crosslinking and immunoprecipitation),  eFACS (fluorescence-activated cell sorting of embryos), SILAC and pulsed SILAC (stable isotope labeling by amino acids in culture cells), different sequencing protocols, metabolic profiling and advanced imaging. Capacities and technologies are constantly extending according to the general expansion of the BIMSB.