Single cell approaches for personalized medicine

In order to make the highly innovative single cell approaches clinically usable for effective translation as quickly as possible, BIH is establishing a jointly supported, close interdisciplinary cooperation, in which BIH and Charité will contribute clinic-related expertise (bioinformatics, imaging, machine learning, oncology, neurology, dermatology, biobanks, diagnostics and biomarkers) and the MDC-Mitte (BIMSB) technological and scientific expertise in the field of single cell biology and gene regulation.

The implementation is based on two pillars:

The establishment of four bridge junior research groups from BIH, MDC-Mitte (BIMSB) and Charité, which bring single cell expertise into clinical application. These junior research groups are located in the BIMSB building, where they have access to the latest single cell approaches and are in close contact with leading international scientists*. At the same time, each of these groups is integrated into a clinic at the Charité where they identify clinically relevant topics, use and develop single cell approaches to address specific clinical issues and establish the technologies for clinical use. This bridge concept optimally combines the internationally leading position of the BIMSB in the development of single cell approaches with the clinical-translational potential of BIH/Charité.

The development of a "Clinical Single Cell Sequencing" pipeline, which includes a central bioportal (patient sample collection, characterization and processing) as well as an integrated workflow with relevant genomics and bioinformatics services for the participating clinics.

Steering Committee

 

Speaker

Prof. Dr. Nikolaus Rajewsky

87: Timoféeff-Ressovsky-Haus

Room: 1.09

rajewsky@mdc-berlin.de

+49 30 9406-2999

Co-Speaker

Prof. Dr. Angelika Eggert
Director Department of Paedriatrics, Department of Oncology and Hematology
Charité – Universitätsmedizin Berlin

Members

Prof. Dr. Frank Heppner
Director Institute of Neuropathology
Charité – Universitätsmedizin Berlin

Prof. Dr. Norbert Hübner
Head of the lab "Genetics and Genomics of Cardiovascular Diseases"
MDC

Dr. Jan Philipp Junker
Head of the lab "Quantitative Developmental Biology"
MDC

Prof. Dr. Ulrich Keilholz
Director Charité Comprehensive Cancer Center (CCCC)
Charité – Universitätsmedizin Berlin

Prof. Dr. Ana Pombo
Head of the lab "Epigenetic Regulation and Chromatin Architecture"
MDC

Prof. Dr. med. Frank Tacke
Department Head, Department of Hepatology and Gastroenterology
Charité – Universitätsmedizin Berlin
 

BIH-CSCS-Pipeline Governance Board

(reporting to the steering committee)

Chair

Prof. Dr. Ulrich Keilholz
Direktor des Charité Comprehensive Cancer Center (CCCC)
Charité – Universitätsmedizin Berlin

Members

Prof. Dr. Angelika Eggert
Director Department of Paedriatrics, Department of Oncology and Hematology
Charité – Universitätsmedizin Berlin

Prof. Dr. Frank Heppner
Director Institute of Neuropathology
Charité – Universitätsmedizin Berlin

Prof. Dr. Ana Pombo
Head of the lab "Epigenetic Regulation and Chromatin Architecture"
MDC

Prof. Dr. Uwe Ohler
Head of the lab "Computational Regulatory Genomics"
MDC

Single-Cell Tech leader (TBA)
MDC
 

Further links and information
 

Press Release No. 3 February 05, 2020 Berlin

BIH, MDC und Charité launch a new research focus

• The LifeTime Initiative
• Gene Technology Report: "EINZELZELLANALYSE IN FORSCHUNG UND MEDIZIN" (German only)
• Helmholtz interview with Nikolaus Rajewsky: "Jede einzelne Zelle im Blick" (German only)
• Single Cell Omics Germany