de la Rosa lab

de la Rosa Lab

Cancer & Immunology / Immune Mechanisms and Human Antibodies


Our lab has a strong focus on human immunology, which stems from the fundamental need to deeply understand the human immune system to combat diseases. Particularly, we study B cells, the type of immune cells that produce antibodies.

An enormous diversity of antibodies protects us from various infectious diseases by binding and neutralizing pathogens. During an infection, B cells undergo maturation processes including the acquisition of beneficial mutations followed by subsequent selection to increase the potency of antibodies. However, for some diseases the body’s immune system fails to induce natural protection. We study antibody maturation to understand how diversity is generated and which determinants are important to elicit potent protection. 

Using high-throughput cellular and molecular screening methodologies, in vitro cultivation methods, and functional studies, our laboratory seeks out novel applications for B cells and antibodies to preserve human health.





Anthony Marchand

MSc Student
September 2019 – March 2020

Subsequent position: PhD Student, protein engineering, EPFL (École polytechnique fédérale de Lausanne), Switzerland



Špela Knez

Erasmus student
April 2019 – August 2019

Subsequent position: PhD student, biotechnology and immunology, University of Ljubljana, Slovenia



Svetlana Khorkova

MSc student
September 2018 – April 2019

Master thesis on "A method to detect transchromosomal insertions in immunoglobulim transcripts." 

Subsequent position: PhD students program IMPRS at the Max Planck Institute for Immunobiology and Epigenetics Freiburg im Breisgau, Germany

Dr. Kathrin de la Rosa
Dr. Kathrin de la Rosa
née Kathrin Pieper