In order to detect disease mechanisms and develop novel molecules for therapeutic intervention, a deep understanding of molecular processes and interactions in healthy and diseased cells is required. We aim to identify soft spots within molecular machines as targets for rational therapies.
We analyze the structure and dynamics of protein complexes with the help of advanced techniques such as cryogenic electron microscopy (cryo-EM), super-resolution microscopy and spatial proteomics. Our aim is a better understanding of protein dysfunction in disease and the identification of small drug-like molecules for therapeutic intervention.
Dr. Michael Strehle