proteine

Farewell Symposium for Thomas Sommer

Targeted proteolysis: From basic discovery to clinical application

Join us for a special scientific symposium as we celebrate the remarkable career of Professor Thomas Sommer. For more than three decades, Thomas Sommer has pioneered research on ubiquitin and targeted proteolysis at the Max Delbrück Center, providing key insights into how misfolded proteins are identified and degraded within cells. In addition to his outstanding scientific achievements, he has also served as a director at the Max Delbrück Center, shaping the institute’s scientific direction and ambition. As he embarks on the next chapter of his career, we honor his legacy and the profound impact of his work on targeted proteolysis and beyond. 


The event will bring together leading researchers from around the world to share insights into the latest advances in ubiquitin biology and targeted proteolysis. Special emphasis will be placed on recent developments in the rapidly evolving field of targeted protein degradation (TPD), which has progressed from proof of concept to the development of degrader drugs currently in clinical trials. The symposium will prioritize in-person exchanges to maximize interactions, stimulate questions, and foster new collaborations.

 

Confimed Speakers

Aaron Ciechanover
Technion - Israel Institute of Technology, Haifa

Ivan Đikić 
Goethe University, Frankfurt   

Fleur M. Ferguson
University of California, San Diego

Ruth Geiss-Friedlander
Albert Ludwig University, Freiburg

Sonja Lorenz
MPI for Multidisciplinary Sciences, Göttingen

Radosław Nowak
University of Bonn

Michael Potente
Berlin Institute of Health at Charité

Brenda Schulman
MPI of Biochemistry, Martinsried

Preliminary Program

TARGETED PROTEOLYSIS: FROM BASIC DISCOVERY TO CLINICAL APPLICATION

08:30Registration and welcome coffee
09:00

Opening and Welcome

Maike Sander, Scientific Director, Max Delbrück Center, Berlin                                                    

 Chair: tba
09:15Keynote lecture
The Embarrassingly Simple Discovery of the Ubiquitin System 
Aaron Ciechanover, Technion - Israel Institute of Technology, Haifa
10:00E3 Ligase Mechanisms: From Endogenous Regulation to Targeted Protein Degradation
Brenda Schulman, MPI of Biochemistry, Martinsried
10:30Coffee break
 Chair: Evangelia Nathanail, Max Delbrück Center, Berlin
11:00Specificity Mechanisms of HECT-Type Ubiquitin Ligases
Sonja Lorenz, MPI for Multidisciplinary Sciences, Göttingen
11:30Tba
Ruth Geiss-Friedlander, Albert Ludwig University, Freiburg
12:00Lunch break
 Chair: Joseph Lim, Max Delbrück Center, Berlin
13:15Targeting Ubiquitin and Autophagy Networks in Cancer
Ivan Đikić, Goethe University, Frankfurt
13:45Keynote lecture
Interrogating the Druggable Proteome with Proximity Pharmacology
Fleur M. Ferguson, University of California, San Diego
14:30Coffee break
 Chair: Jorge Andrade, Max Delbrück Center, Berlin
15:00Targeting C2H2 Transcription Factors for Degradation with Molecular Glues 
Radosław Nowak, University of Bonn
15:30Deconvolution of Complex Biological (vascular) Processes Through Targeted Protein Degradation 
Michael Potente, Max Delbrück Center
16:00Official farewell 
conclusions Thomas Sommer, Maike Sander
17:00Reception
18:00After hour
How to get to the venue

Directions to Campus Berlin-Buch

Venue

Max Delbrück Center
Robert-Rössle-Straße 10
13125 Berlin
Deutschland

Zeit

-
Campus Plan

Organisator*innen

Oliver Daumke

 

If you have any questions, please contact events@mdc-berlin.de.