Do metabolic fluxes change with age?
Autor/innen
- Sebastian J. Hofer
- Anna Katharina Simon
- Frank Madeo
Journal
- Trends in Endocrinology and Metabolism
Quellenangabe
- Trends Endocrinol Metab 37 (4): 294-296
Zusammenfassung
Metabolomes change with age. Yet, fluxomics points to a contradiction: Jankowski et al. in Cell Metabolism report shifts in metabolite concentrations in aged mice, alongside largely preserved metabolite fluxes, evoking important questions on the nature of age-related metabolic disturbances. We discuss how this might recalibrate our understanding of aging metabolism.