Thera-GAM

Challenge

Genetic variation in non-coding regulatory regions accounts for up to 90% of heritability in neurological disorders. These disorders often have missed diagnoses, as well as poor prognoses and treatment outcomes. Current approaches fail to capture targets of these regulatory regions, missing key targets for treatment.

Solution

Thera-GAM is a patented 3D genome mapping technology which captures disruptions in gene-regulatory networks to connect genetics with molecular mechanisms for disease detection and therapeutic target discovery.

A versatile platform which maps gene-variant interactions for therapeutic target discovery

Genome Architecture Mapping (GAM) profiles 3‑dimensional genome structure in single cells directly from patient samples
GAM captures spatial interactions between genomic variants and target genes in complex diseases (e.g. cancer, epilepsy, Alzheimer’s)
RNA-GAM extends the scope by measuring gene expression simultaneously with genome interactions enabling cell state discovery
Highly scalable with all experimental steps automated, enabling rapid collection of large datasets at low cost

Development status

TRL 3 – 4
Proof of concepts in human epilepsy and glioma identified potential therapeutic targets
Current proof of concept ongoing in neuroblastoma, together with validation partner

Applications