Genome architecture mapping detects transcriptionally active, multiway chromatin contacts
Autor/innen
- C.J. Thieme
- A. Pombo
Journal
- Nature Methods
Quellenangabe
- Nat Methods 20 (7): 993-994
Zusammenfassung
Genome architecture mapping (GAM) enables understanding of 3D genome structure in the nucleus. We directly compared multiplex-GAM and Hi-C data and found that local chromatin interactions were generally detected by both methods, but active genomic regions rich in enhancers that established higher-order contacts were preferentially detected by GAM.