Rats overexpressing the dopamine transporter display behavioral and neurobiological abnormalities with relevance to repetitive disorders

Autor/innen

  • R. Hadar
  • H. Edemann-Callesen
  • C. Reinel
  • F. Wieske
  • M. Voget
  • E. Popova
  • R. Sohr
  • Y. Avchalumov
  • J. Priller
  • C. van Riesen
  • I. Puls
  • M. Bader
  • C. Winter

Journal

  • Scientific Reports

Quellenangabe

  • Sci Rep 6: 39145

Zusammenfassung

  • The dopamine transporter (DAT) plays a pivotal role in maintaining optimal dopamine signaling. DAT-overactivity has been linked to various neuropsychiatric disorders yet so far the direct pathological consequences of it has not been fully assessed. We here generated a transgenic rat model that via pronuclear microinjection overexpresses the DAT gene. Our results demonstrate that DAT-overexpression induces multiple neurobiological effects that exceeded the expected alterations in the corticostriatal dopamine system. Furthermore, transgenic rats specifically exhibited behavioral and pharmaco-therapeutic profiles phenotypic of repetitive disorders. Together our findings suggest that the DAT rat model will constitute a valuable tool for further investigations into the pathological influence of DAT overexpression on neural systems relevant to neuropsychiatric disorders.


DOI

doi:10.1038/srep39145