PUBLICATION: A three-dimensional map of the genome
Gene mapping technique promises to unlock the power of proximity to find genes implicated in diseases.
Cells face a daunting task. They have to neatly pack a several meter-long thread of genetic material into a nucleus that measures only five micrometers across. This origami creates spatial interactions between genes and their switches, which can affect human health and disease. Now, an international team of scientists has devised a powerful new technique that ‘maps’ this three-dimensional geography of the entire genome.
STUDENT UPDATE: Christin Zasada successfully defends her doctoral thesis
Christin Zasada, Kempa group, has successfully defended her doctoral thesis “Experimental and mathematical analysis of the central carbon metabolism in cancer and stem cells" with the grade magna cum laude at the Institute of Biology of the Humboldt-Universität zu Berlin on February 22, 2017.
Thesis reviewers: H. Holzhuetter, E. Klipp, M. Landthaler
Doctoral commission: T. Sommer, E. Klipp, A. Pombo, H. Holzhuetter and M. Landthaler
This research was funded by the BMBF and the MDC.
STUDENT UPDATE: Mahmoud Ibrahim successfully defends his doctoral thesis
Mahmoud Ibrahim, Ohler group, has successfully defended his doctoral thesis "Promoter and Enhancer Chromatin Dynamics during Direct Cell Fate Programming" with the grade summa cum laude at the Institute of Biology of the Humboldt-Universität zu Berlin on February 17, 2017.
Thesis reviewers: U. Ohler, E. Mazzoni and M. Vingron
Doctoral commission: L. Ringrose, M. Vingron, U. Ohler, A. Pombo and E. Mazzoni.
This research was funded by the MDC-NYU PhD Exchange Program and was jointly conducted with the laboratory of Esteban Mazzoni at NYU.
SEMINAR SERIES: Alexander van Oudenaarden - Distinguished Speaker in the BIMSB Seminar Series
On February 14, 2017, we had the pleasure to host Alexander van Oudenaarden, director of the Hubrecht Institute in Utrecht, as a distinguished speaker in our seminar series. Alexander is a world-leader in systems biology of single cells. At the Berlin Institute of Medical Systems Biology he spoke about systematic approaches to identify novel cell types and about emerging methods for determining cell-cell interactions and lineage history by single cell sequencing.
In addition to meetings with individual group leaders and discussions with PhD students and postdocs over lunch and dinner, Alexander also gave the closing lecture of our lecture series on single cell technologies on February 15.
Of bits, bytes, and bacteria: a week of systems biology at the MDC
Can the lives of microorganisms be described through mathematics? It is one of the questions that pupils participating in the MINT Excellence Academy in “Systems Biology” have asked scientists during their visit to the MDC from Feb 6 to 10 this year. Twenty pupils from across Germany have come to catch a glimpse of how researchers combine laboratory and computational science into models of biological processes.
Algorithms help navigate through the data thicket of biological systems
If one looks beyond individual molecules, biology quickly becomes complex. All life processes seem to affect one another. The computer scientist Uwe Ohler and his team of researchers at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) are using algorithms and mathematical models to map a path through this tangle of dependencies.
STUDENT UPDATE: Kathrin Theil successfully defends her doctoral thesis
Kathrin Theil, N Rajewsky group, has successfully defended her doctoral thesis "Identification and characterization of regulatory protein-RNA interactions in the C. elegans germline" with the grade magna cum laude at the Institute of Biology of the Humboldt-Universität zu Berlin on January 17, 2017.
Thesis reviewers: N. Rajewsky, C. Schmitz-Linneweber and T. Sommer
Doctoral commission: A. Herrmann, N. Rajewsky, C. Schmitz-Linneweber, T. Sommer and A. Pombo